Nevertheless, there are few reports on BTMs changes after osteoporotic vertebral compression fracture (OVCF). Osteoporotic fracture occurs mostly at the spine, in which the commonest one is vertebral compression fracture. Among them, PINP and CTX have been recommended as the main reference markers of bone metabolism in predicting fracture risk and evaluating anti-osteoporosis treatment by the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry (IFCC) Bone Marker Standards Working Group. The other BTMs include osteocalcin (OC) and alkaline phosphatase (ALP). The commonest bone formation marker is type I procollagen amino- or carboxyl-terminal peptides (PICP or PINP) which is the breakdown product dissociated from type I procollagen. Bone resorption markers are mainly the breakdown products of type I collagen, among which the widely used one is type I collagen amino- or carboxyl-terminal peptides (NTX or CTX). īTMs comprise of two categories: bone resorption markers and formation markers. BTMs could enhance the evaluation efficiency for the bone fracture healing, as well as predict early the risk of developing impaired fracture outcomes. Bone biochemical markers (BTMs) help to monitor the bone metabolic rate quantitatively. However, osteoporosis could delay fracture healing and impair healing outcomes. įracture healing can be divided into three phases: the inflammation phase, the regeneration phase, and the remodeling phase. Osteoporotic fracture has become a global health care issue, due to high mortality and costs. It is helpful to assess vertebral fracture healing process according to the kinetics of BTMs.Īlong with the aging population increases to be double in the next decades, the incidence of osteoporosis will rise obviously, which makes the bone fragile and liable to fracture. Kinetics of BTMs after vertebral fracture as well as the reference value at each period were established in the present study. The time-dependent variations of BTMs based on the fracture healing process of inflammation, regeneration, and remodeling occur after vertebral fracture. Serum calcium reached the first peak (2.30 ± 0.07 mmol/L) in phase 3 and the second peak (2.34 ± 0.08 mmol/L) in phase 5. Serum phosphorus arrived at its first peak (1.21 ± 0.13 mmol/L) in phase 2 and the second peak (1.23 ± 0.13 mmol/L) in phase 4. PINP reached its peak value (69.50 ± 16.82 ng/ml) in phase 6. The peak of ALP arrived in phase 4 at the value of 123.9 ± 25.7 U/L.
ResultsĪll the kinds of BTM’s serum concentration began to increase within 3 days after vertebral fracture in phase 1. Comparisons among the phases and kinetics during the phases were conducted. According to periods long after vertebral fracture, all the cases were divided into seven phases: phase 1 (within 3 days), phase 2 (3 days to 1 week), phase 3 (1 to 2 weeks), phase 4 (2 to 4 weeks), phase 5 (4 to 12 weeks), phase 6 (12 to 24 weeks), and phase 7 (24 weeks to 1 year). Fasting blood samples were obtained to analyze the serum concentration of bone turnover markers including osteocalcin (OC), β-isomerized type I collagen amino-terminal peptide (β-CTX), alkaline phosphatase (ALP), type I procollagen amino-terminal peptides (PINP), calcium, and phosphorus. Three hundred nine postmenopausal female patients with osteoporotic vertebral compression fractures were included in the study. The aim of this study is to investigate the kinetics of bone turnover markers after osteoporotic vertebral compression fractures in postmenopausal female. Nevertheless, there are few reports on BTMs changes after osteoporotic vertebral compression fracture. Bone turnover markers (BTMs) can be applied to assess bone formation and resorption activity.
0 kommentar(er)
